It’s good to see some progress being made towards the recognition of cognitive impairment in schizophrenia and looking at possible treatment options:
http://www.needrecognition.com
Cognitive symptoms, which may include deficits in memory, attention, working memory, processing speed, and problem solving
- Can be present prior to the onset of illness
- Persist during periods of psychotic symptom remission
- Are highly predictive of outcome and functioning
Despite the availability of effective antipsychotic therapy, cognitive impairment remains an important unmet treatment need
Proposed Mechanisms of Cognitive Impairment in Schizophrenia
Interventions:
- Cognitive remediation
- The MATRICS team identified drug mechanisms of interest, including cholinergic, dopaminergic, and glutamatergic approaches
- Of the cholinergic approaches, the α7 was identified as a top target of investigation
Potential Mechanistic Targets for Treatment of Cognitive Impairment in Schizophrenia
| CHOLINERGIC |
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| DOPAMINERGIC |
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| GLUTAMATERGIC |
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| OTHER |
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See more:
Pharmacological Treatment of Cognitive Symptoms
The Magic of Movement; the Potential of Exercise to Improve Cognition (2015)
Cognitive enhancing agents in schizophrenia and bipolar disorder (2015)
Drug repurposing and emerging adjunctive treatments for schizophrenia (2015)
Sex hormones and oxytocin augmentation strategies in schizophrenia: A quantitative review (2015)
Adjunctive Minocycline in Clozapine-Treated Schizophrenia Patients With Persistent Symptoms (2015)
A critical review of pro-cognitive drug targets in psychosis: convergence on myelination and inflammation
Psychopharmacological treatment of neurocognitive deficits in people with schizophrenia: a review of old and new targets.
advancingschizophreniatherapeutics 