Cyproheptadine for sleep?

I’m getting pretty desperate for a good sleep [a few things in life are really stressing me out] even when aiming for more physical activity to tire myself out. I’ve stopped using doxylamine (noticing anticholinergic side-effects and at my psychiatrist’s recommendation) and olanzapine wasn’t cutting it, not being a great sedative without personally gaining weight quickly. Coming off a few weeks of diazepam isn’t helping the situation so I settled on a short trial of cyproheptadine (OTC in Australia). I’m worried about increased appetite and the other adverse effects but optimistic about the following:

Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats.

The present study was undertaken to investigate the effects of some H(1)-antagonists on the sleep-wake cycle in sleep-disturbed rats in comparison with those of nitrazepam. Electrodes were chronically implanted into the frontal cortex and the dorsal neck muscle of rats for the electroencephalogram (EEG) and electromyogram (EMG), respectively. EEG and EMG were recorded with an electroencephalograph. SleepSign ver. 2.0 was used for EEG and EMG analysis. The total times of waking, non-rapid eye movement (non-REM), and rapid eye movement (REM) sleep were measured from 10:00 to 16:00. Nitrazepam showed a significant decrease in sleep latency, total waking time, and delta activity and an increase in the total non-REM sleep time. A significant decrease in the sleep latency was observed with diphenhydramine, chlorpheniramine, and cyproheptadine. Cyproheptadine also caused a significant decrease in the total waking time and increases in total non-REM sleep time, REM sleep time, slow wave sleep, and delta activity, although no remarkable effects were observed with diphenhydramine and chlorpheniramine. In conclusion, cyproheptadine can be useful as a hypnotic, having not only sleep inducing-effects, but also sleep quantity- and quality-increasing effects.

Added to that:

“According to a small study, cyproheptadine hydrochloride has been found to improve sleep, calmness, and mood and energy levels, and to improve both negative and (sometimes even) positive psychotic symptoms in a subgroup of chronic schizophrenics who did not respond (either completely or sufficiently) to other therapies

Cyproheptadine may improve akathisia in patients on antipsychotic medications”

Managed to get a decent sleep on 4mg the first night but did notice the extra eating and residual daytime grogginess. The second night was plagued by the dreaded ‘nighttime hunger awakenings and feasts’ and not much sleep… This might be a short trial…

Update: Ended getting stressed to the point of tachycardia so propranolol ended up being a better aid. Feel much better.

Next step if this doesn’t work is consulting my excellent Dr

Cyproheptadine as a hypnotic – discussion

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